منابع مشابه
General Chemical and Experimental Data on Carcinogenesis and Tobacco Smoke
polynuclear Aromatic Bydromrbons As criteria for the presence of polynuclear aromatic hydrocarbons in tobacco smoke, the list of J. W. Cook (m) has been widely accepted by tobacco chemists. The Surgeon General’s 1964 Report and Cook’s paper are in agreement with respect to the presence of benzo(a)pyrene (3 : 4benzopyrene) , dibenz (a,h) -anthracene (12 : 5,6-dibenzanthrac) : benzo(c) phenanthre...
متن کاملLung carcinogenesis: pivotal role of metals in tobacco smoke.
Although significant progress has been made in unraveling the molecular mechanisms responsible for tobacco smoke toxicity and carcinogenicity, only limited information is available concerning the mechanisms by which tar particles and the gaseous phase constituents of tobacco smoke participate and contribute to carcinogenic processes in lung cancer. The present review critically evaluates how me...
متن کاملChemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure.
Male strain A/J mice were exposed for 6 h per day, 5 days per week to a mixture of 89% cigarette sidestream smoke and 11% mainstream smoke. Total suspended particulate concentrations were 137 mg/m(3). In experiment 1, animals were exposed for 5 months to tobacco smoke and given a 4 month recovery period in air. Lung tumor multiplicity was 2.4 and incidence 89%. Animals exposed to filtered air h...
متن کاملAssay of lapatinib in murine models of cigarette smoke carcinogenesis.
Lapatinib, a dual tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2), is prescribed for the treatment of patients with metastatic breast cancer overexpressing HER-2. Involvement of this drug in pulmonary carcinogenesis has been poorly investigated. We used murine models suitable to evaluate cigarette smoke-related...
متن کاملA mouse lung tumor model of tobacco smoke carcinogenesis.
We examined the possibility of developing an animal model of tobacco smoke carcinogenesis. Male Balb/c and SWR mice were exposed for 5 months to tobacco smoke (6 h/day, 5 days/week; average concentration, 122 mg/m(3) of total suspended particulates [TSP]) followed by a recovery period of 4 months in air. In both strains there was an increase in lung tumor multiplicities and incidence, although ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1959
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5130.1186